Body mass components affecting low-attenuation noncalcified coronary plaque burden

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): National Institute Cardiology in Warsaw, Poland Background Weight control is a major risk modifier for coronary artery disease. However, the effect exerted by individual body mass components on plaque may not be uniform. Low-attenuation noncalcified (LAP) has been recently identified as an independent predictor cardiovascular outcomes [1]. Purpose To determine relationship between changes composition and LAP burden. Methods 89 participants Dietary Intervention to Stop Coronary Atherosclerosis Computed Tomography (DISCO-CT) were enrolled into analysis (40% women, mean age 60±7.7 years). Patients with non-obstructive (stenosis<70%) atherosclerosis confirmed computed tomography angiography (CCTA) qualified conservative treatment randomized (1:1) intensive diet lifestyle intervention atop optimal medical therapy (OMT) versus OMT alone over 66.8±13.7 months [2]. Body (BM) including total fat (TBF), skeletal muscle (SMM), visceral cell (VCM), extracellular (ECM) measured at baseline follow-up (InBody S10 analyser, South Korea). burden was defined volume <30 Hounsfield units divided vessel volume, expressed %. Changes compared serial CCTA scans (QAngioCT, Medis Medical Imaging Systems, Netherlands). Results Reduction BM significantly higher experimental (∆BM=-3.6±4.9 kg) vs arm (∆BM=-1.4±2.9 kg; p = 0.016) so reduction TBF (∆TBF=-4.2±5.3 kg ∆TBF=0.2±4.3 kg, respectively; p<0.001). SMM increased 0.4±2.6 decreased 1.0±2.1 (p 0.006). No significant interarm differences observed VCM ECM. (∆LAP=-0.42±1.4% ∆LAP=-0.03±0.45%, 0.078). In entire study population, positive correlation revealed (r=0.45, Multivariate regression model incorporating investigated only component associated (table). Conclusions decrease due reduction.